Figure 3.

Schematic diagram depicting functions of cohesin at noncentromeric sites. (a) Double‐strand break (DSB) repair is facilitated by cohesin binding to the break site. Cohesion is also re‐enforced genome‐wide in response to a DSB. (b) Cohesin regulates gene expression by gene looping to promote long‐range (1) promoter–enhancer communication, (2) promoter–terminator interaction (middle), or (3) insulation. These types of events may contribute to chromatin organization within topological domains. (c) Cohesin promotes chromosome condensation.