Table 3.
Reported thyroid‐stimulating hormone reference ranges by age in reference populations free of thyroid disease and risk factors for thyroid disease
| TSH Concentration, mIU/l | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Surks and Hollowell, 2007* 26 | Boucai et al., 2011 28 | Bremner et al., 2012 67 | Waring et al., 2012† 68 | ||||||||
| Age range, years | Median | 97.5th percentile | 2.5th percentile | Median | 97.5th percentile | Lower limit‡ | Mean | Upper limit‡ | 2.5th percentile | Median | 97.5th percentile |
| 12–19§ , ¶ | 1.35 | 4.07 | 0.41 | 1.30 | 3.78 | 0.51 | 1.34 | 3.54 | |||
| 20–29 | 1.26 | 3.56 | 0.40 | 1.30 | 3.60 | ||||||
| 30–39** | 1.29 | 3.69 | 0.38 | 1.25 | 3.60 | 0.48 | 1.25 | 3.21 | |||
| 40–49†† | 1.40 | 3.82 | 0.44 | 1.40 | 3.90 | 0.44 | 1.32 | 3.92 | |||
| 50–59‡‡ | 1.50 | 4.03 | 0.49 | 1.50 | 4.20 | 0.42 | 1.31 | 4.09 | |||
| 60–69§§ | 1.67 | 4.33 | 0.46 | 1.66 | 4.70 | 0.38 | 1.34 | 4.70 | |||
| 70–79¶¶ | 1.76 | 5.90 | 0.47 | 1.74 | 5.60 | 0.52 | 1.66 | 5.28 | 0.71 | 1.56 | 2.67 |
| 80–84*** | 1.90 | 7.49 | 0.44 | 1.90 | 6.30 | 0.60 | 2.20 | 6.16 | |||
| 85–89 | 0.51 | 2.59 | 6.41 | ||||||||
| ≥ 90 | 0.20 | 2.53 | 7.96 | ||||||||
*2.5th percentile not reported. †Study included only an elderly population. ‡Mean ± 2 SD of log‐transformed serum TSH concentrations. §13–19 for Boucai et al. ¶< 30 for Bremner et al. **30–40 for Bremner et al. ††40–50 for Bremner et al. ‡‡50–60 for Bremner et al. §§60–70 for Bremner et al. ¶¶> 70 for Bremner et al.; 75–79 for Waring et al. ***≥ 80 for Surks and Hollowell and Boucai et al. TSH, thyroid‐stimulating hormone.