Table 1.
Summary of lacZ Mutant Frequency in Sperm from the Cauda Epididymis of Muta™Mouse Males Exposed Acutely or Subchronically to ENU
| Experiment | Dose (mg/kg) | n | # Plaques | # Mutants | Avg MFa (×105) | SDa (×105) | P value |
|---|---|---|---|---|---|---|---|
| Acute | 0 | 8 | 1,884,624 | 39 | 2.3 | 1.1 | – |
| 25 | 6 | 1,015,702 | 67 | 6.7 | 2.8 | 0.003 | |
| 50 | 8 | 1,296,012 | 134 | 10.7 | 3.8 | <0.001 | |
| 100 | 8 | 1,560,910 | 177 | 11.5 | 4.9 | <0.001 | |
| Subchronic | 0 | 6 | 1,356,479 | 42 | 3.1 | 1.2 | – |
| 28 | 7 | 1,664,619 | 67 | 4.0 | 1.4 | 0.595 | |
| 56 | 6 | 1,439,974 | 55 | 3.9 | 1.3 | 0.958 | |
| 140 | 7 | 1,346,538 | 128 | 9.5 | 3.9 | 0.005 |
a
Average mutant frequency (Avg MF) and standard deviation (SD) are based on the arithmetic mean for individual animals.