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Diagnostic performances of serum metabolite panel (2‐Meta), AFP, and both in the diagnosis of HCC and S‐HCC. (A‐C) Diagnostic accuracy of 2‐Meta in the individuals from groups CHB, Cir, HCC, and S‐HCC or falsely diagnosed patients by AFP in the discovery, test, and validation (cohort 1) sets, respectively. AFP+, false‐positive AFP (CHB and Cir patients with AFP >20 ng/mL), AFP–, false‐negative AFP (HCC and S‐HCC patients with AFP <20 ng/mL).
