Table 2.
Results of Measurement of the Serum Metabolite Panel, AFP, or Both in the Diagnosis of HCC
| Discovery Set | Test Set | Validation Set (Cohort 1) | |||||||
|---|---|---|---|---|---|---|---|---|---|
|
AUC (95% CI) |
Sensitivity (%) |
Specificity (%) |
AUC (95% CI) |
Sensitivity (%) |
Specificity (%) |
AUC (95% CI) |
Sensitivity (%) |
Specificity (%) |
|
| HCC versus non‐HCC | |||||||||
| 2‐Meta | 0.951 (0.914‐0.989) | 88.9 | 88.9 | 0.936 (0.917‐0.955) | 88.6 | 85.7 | 0.875 (0.846‐0.905) | 91.6 | 72.2 |
| HCC versus Cir | |||||||||
| 2‐Meta | 0.930 (0.871‐0.988) | 88.9 | 82.9 | 0.892 (0.856‐0.929) | 86 | 78.4 | 0.807 (0.753‐0.861) | 92.1 | 52.8 |
| AFP | 0.657 (0.528‐0.786) | 61.8 | 56.1 | 0.725 (0.671‐0.779) | 56.4 | 78.4 | 0.650 (0.582‐0.718) | 50.4 | 73.2 |
| 2‐Meta+AFP | 1.000 (1.000‐1.000) | 100 | 100 | 0.905 (0.872‐0.938) | 81.4 | 87.4 | 0.826 (0.774‐0.877) | 77.9 | 76.4 |
| HCC versus (CHB and Cir) | |||||||||
| 2‐Meta | — | — | — | — | — | — | 0.826 (0.779‐0.873) | 92.1 | 63.8 |
| AFP | — | — | — | — | — | — | 0.682 (0.620‐0.745) | 50.4 | 78.4 |
| 2‐Meta+AFP | — | — | — | — | — | — | 0.847 (0.803‐0.891) | 77.9 | 78.4 |
| S‐HCC versus Cir | |||||||||
| 2‐Meta | — | — | — | 0.866 (0.816‐0.916) | 80.2 | 78.4 | 0.753 (0.664‐0.843) | 80.6 | 52.8 |
| AFP | — | — | — | 0.682 (0.607‐0.757) | 45.3 | 78.4 | 0.676 (0.575‐0.778) | 55.6 | 73.2 |
| 2‐Meta+AFP | — | — | — | 0.870 (0.820‐0.919) | 74.4 | 87.4 | 0.774 (0.688‐0.861) | 66.7 | 76.4 |
| S‐HCC versus (CHB and Cir) | |||||||||
| 2‐Meta | — | — | — | — | — | — | 0.771 (0.689‐ 0.854) | 80.6 | 63.8 |
| AFP | — | — | — | — | — | — | 0.711 (0.614‐0.808) | 55.6 | 78.4 |
| 2‐Meta+AFP | — | — | — | — | — | — | 0.801 (0.722‐0.878) | 66.7 | 78.4 |
Abbreviations: CI, confidence interval; 2‐Meta, serum metabolite panel.