Level of evidence | Level of agreement | |
---|---|---|
Patients with recurrent C. difficile infection with at least two previous standard treatments without persistent cure should be considered for FMT | HIGH | 100% |
Both standard or family/same household donors are applicable | HIGH | 100% |
If possible, patients should be included in a national registry | NA | 100% |
Faecal samples from patients before and after the treatment, if possible, as well as a donor sample, should be collected for follow‐up in case of adverse events | NA | 100% |
So far, it is still unclear if antibiotic treatment and/or bowel cleansing before FMT is beneficial or if it could negatively affect the outcome (see also ‘Recommendations on preparation of recipient’) | NA | 90% |
No specific route of administration seems to be preferable regarding efficacy. However, preliminary data suggests that application by lower gastrointestinal tract may be safer (see also ‘Recommendations on routes of administration’) | LOW | 90% |
NA, not applicable.