Table 1. The target genes of histone modification and relative clinical consequence.
| Histone modification | Cause | Target gene/Signal | Consequence |
|---|---|---|---|
| H3K9 trimethylation + | Alcohol | VASH2 ↑ | Proliferation + |
| H3K27 trimetylation - | Apoptosis - | ||
| H3K4 trimethylation + | Non-alcohol | FASN ↓ | Insulin resistance |
| H3 acetylation + | |||
| H3K9 acethylation + | HVB | RIZ1 ↓ | Proliferation + |
| H3K9 trimetylation + | |||
| H3K27 acethylation + | Alcohol | P53 ↓ | Aggression + |
| H3K27 trimetylation + | Invasion + | ||
| H3K27 acethylation + | Alcohol | FBP1 ↓ | Metabolism and poor prognosis |
| H3K4 trimethylation + | MLL | HGF ↑ | Proliferation + |
| Metastasis - | |||
| H3K4 trimethylation + | Chemicals | YAP1 ↑ | Proliferation + |
| Inflammation - | |||
| H3K9 trimethylation + | HVB | P16 ↓ | Proliferation + |
| H3K4 trimethylation + | CHC | TSG ↓ | Proliferation + |
| H3K16 acethylation + | |||
| H3K4 dimethylation - | Linc00441 | RB1 ↓ | Proliferation + |
| H3K27 acetylation + | Apoptosis - | ||
| H3K27 acetylation + | Lnc-Myd88 | NF-kB ↑ | Proliferation + |
| Metastasis + |