Table 3.
Top 20 significant metabolites identified on the meta-analysis of the two cohorts for the comparison across all study groups.
| Super Pathway | Sub Pathway | Metabolite | OR PT | Pval PT | OR US | Pval US | OR Meta | Pval Meta | Qval Meta |
|---|---|---|---|---|---|---|---|---|---|
| Amino Acid | Alanine and Aspartate Metabolism | N-acetylasparagine | 1.23 | 1.16 × 10−2 | 1.74 | 1.00 × 10−6 | 1.37 | 6.10 × 10−7 | 1.65 × 10−4 |
| Amino Acid | Methionine, Cysteine, SAM, and Taurine Metabolism | Hypotaurine | 1.49 | 1.00 × 10−6 | 1.19 | 1.08 × 10−1 | 1.37 | 1.21 × 10−6 | 1.65 × 10−4 |
| Amino Acid | Glutamate Metabolism | Beta−citrylglutamate | 1.26 | 3.40 × 10−3 | 1.46 | 3.50 × 10−4 | 1.32 | 6.67 × 10−6 | 4.21 × 10−4 |
| Amino Acid | Leucine, Isoleucine, and Valine Metabolism | N-acetylleucine | 1.18 | 4.62 × 10−2 | 1.43 | 7.30 × 10−4 | 1.27 | 2.69 × 10−4 | 7.80 × 10−3 |
| Carbohydrate | Glycogen Metabolism | Maltotriose | 1.43 | 1.00 × 10−6 | 1.11 | 2.88 × 10−1 | 1.31 | 6.19 × 10−6 | 4.21 × 10−4 |
| Carbohydrate | Glycogen Metabolism | Maltose | 1.38 | 3.00 × 10−5 | 1.15 | 1.60 × 10−1 | 1.29 | 3.17 × 10−5 | 1.72 × 10−3 |
| Lipid | Lysoplasmalogen | 1-(1-enyl-palmitoyl)-GPE (P-16:0) * | 1.21 | 1.62 × 10−2 | 1.95 | 1.00 × 10−6 | 1.48 | 9.86 × 10−7 | 1.65 × 10−4 |
| Lipid | Phospholipid Metabolism | Phosphoethanolamine | 1.39 | 2.00 × 10−5 | 1.26 | 2.01 × 10−2 | 1.32 | 1.62 × 10−6 | 1.67 × 10−4 |
| Lipid | Diacylglycerol | Oleoyl-oleoyl-glycerol (18:1/18:1) [2] * | 0.86 | 5.74 × 10−2 | 0.62 | 1.00 × 10−6 | 0.76 | 6.96 × 10−6 | 4.21 × 10−4 |
| Lipid | Diacylglycerol | Oleoyl−linoleoyl-glycerol (18:1/18:2) [1] | 0.87 | 7.56 × 10−2 | 0.64 | 1.00 × 10−5 | 0.76 | 4.01 × 10−5 | 1.98 × 10−3 |
| Lipid | Fatty Acid Metabolism(Acyl Carnitine) | Myristoleoylcarnitine (C14:1) * | 0.90 | 2.06 × 10−1 | 0.62 | 1.00 × 10−6 | 0.78 | 6.54 × 10−5 | 2.97 × 10−3 |
| Lipid | Phosphatidylserine (PS) | 1−stearoyl-2-oleoyl-GPS (18:0/18:1) | 1.50 | 1.00 × 10−6 | 1.01 | 9.33 × 10−1 | 1.33 | 8.78 × 10−5 | 3.54 × 10−3 |
| Lipid | Fatty Acid Metabolism(Acyl Carnitine) | Laurylcarnitine (C12) | 0.91 | 2.78 × 10−1 | 0.61 | 1.00 × 10−6 | 0.78 | 1.18 × 10−4 | 4.29 × 10−3 |
| Lipid | Diacylglycerol | Oleoyl-linoleoyl-glycerol (18:1/18:2) [2] | 0.89 | 1.44 × 10−1 | 0.63 | 2.00 × 10−5 | 0.76 | 1.68 × 10−4 | 5.67 × 10−3 |
| Lipid | Fatty Acid Metabolism(Acyl Carnitine) | Decanoylcarnitine (C10) | 0.86 | 5.97 × 10−2 | 0.69 | 2.20 × 10−4 | 0.79 | 1.77 × 10−4 | 5.67 × 10−3 |
| Lipid | Lysoplasmalogen | 1-(1-enyl-oleoyl)-GPE (P-18:1) * | 1.06 | 4.19 × 10−1 | 1.75 | 1.00 × 10−6 | 1.32 | 2.83 × 10−4 | 7.80 × 10−3 |
| Lipid | Diacylglycerol | Oleoyl−oleoyl-glycerol (18:1/18:1) [1] * | 0.86 | 5.14 × 10−2 | 0.70 | 6.50 × 10−4 | 0.79 | 2.87 × 10−4 | 7.80 × 10−3 |
| Nucleotide | Pyrimidine Metabolism, Cytidine containing | Cytidine | 1.31 | 9.10 × 10−4 | 1.69 | 1.00 × 10−6 | 1.40 | 1.96 × 10−8 | 1.06 × 10−5 |
| Nucleotide | Purine Metabolism, Adenine containing | Adenosine | 1.25 | 3.12 × 10−3 | 1.47 | 7.00 × 10−5 | 1.32 | 1.84 × 10−6 | 1.67 × 10−4 |
| Nucleotide | Pyrimidine Metabolism, Orotate containing | Dihydroorotate | 0.71 | 1.00 × 10−6 | 0.99 | 9.44 × 10−1 | 0.80 | 9.11 × 10−5 | 3.54 × 10−3 |
Legend: OR: odds ratio; PT: Portugal; US: United States; Meta: meta-analysis.