Table 5.
Characteristics of hyaluronic acid (HA) MOF nanomedicines
| Bond | Pore | Cargo | Drug Loading Content (%) | Responsive Stimuli | Therapy Method | Size (nm) | Surface Charge (mV) | HA MW (kDa) | Ref. |
|---|---|---|---|---|---|---|---|---|---|
| Coordination | O | Dox | pH | Chemo, MRI | 150 | −30.2 | X | [94] | |
| O | Indocyanine green | 42 | NIR | PTT, MRI, PA imaging | 106 | −25.4 | X | [98] | |
| O | α-Cyano-4-hydroxy-cinnamate | HAdase, Light | PDT | 152 | −13.9 | X | [99] | ||
| Coordination | O | Cytarabine, indocyanine green | 39.8 | pH | Chemo, PTT | 135 | 10 | [97] |
Dox: Doxorubicin, MRI: magnetic resonance imaging; NIR: Near infrared; PDT: Photodynamic Therapy; PTT: Photothermal Therapy.