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. 2019 Jul 15;11(7):336. doi: 10.3390/pharmaceutics11070336

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Final pharmacokinetic(PK) structure developed based on animal PK, where F_max and F₅₀ is the maximum bioavailability and the amount of dose reaching 50% of the maximum bioavailability, respectively; WB is the time-dependent absorption rate constant following the Weibull distribution α as the scale and β as the shape parameters of the Weibull distribution, respectively; A₁, A_2, and A₃ are the drug amount in the absorption, central, and peripheral compartment, respectively; and CL and Q are the elimination and distribution clearance, respectively.