Table 3.

Changes in hepatic drug-metabolizing enzyme activities in rats ^a.

	Control	HRW
Phase I enzymes (pmol/min/mg protein)
Testosterone 6β-hydroxylase (CYP3A)	682.3 ± 75.6	640.9 ± 168.1
Diclofenac 4-hydroxylase (CYP2C)	155.9 ± 10.3	147.9 ± 8.1
Dextromethorphan O-demethylase (CYP2D)	51.9 ± 6.1	45.2 ± 4.6
Nitrophenol 6-hydroxylase (CYP2E1)	121.1 ± 12.3	109.8 ± 15.6
Ethoxyresorufin O-deethylase (CYP1A1)	167.8 ± 17.2	171.5 ± 10.1
Methoxyresorufin O-demethylase (CYP1A2)	133.2 ± 18.2	140.6 ± 17.4
Pentoxyresorufin O-depentylase (CYP2B)	61.9 ± 10.4	62.3 ± 11.3
Lauric acid 12-hydroxylauric acid (CYP4A)	1524 ± 125	1488 ± 132
Phase II enzymes (nmol/min/mg protein)
Glutathione S-transferase (GST)	1072 ± 175	1132 ± 88
UDP-glucurosyltransferase (UGT)	23.4 ± 2.3	25.5 ± 3.0

^a Results are expressed as the mean ± S.D. of eight rats in each group.