Table 2.
Literature examples of hyaluronic acid association with cationic polymers for siRNA delivery.
| Type of Association between Hyaluronic Acid and Cationic Polymer | Cationic Polymer | Components of the Delivery System | Type of Nanoparticle | In vitro/In vivo Study | Combination Therapy | Ref |
|---|---|---|---|---|---|---|
| Electrostatic interaction | PCD | HA, hyperbranched poly(amido amine) (PCD), siRNA | Polyelectrolyte complex | In vitro | - | [141] |
| PEI | HA-cystamine, Octyl-ss-PEI (reducible bond) or Octyl-cc-PEI (non-reducible bond), paclitaxel, siRNA | Polymeric micelle | In vitro + in vivo | Co-delivery: siRNA paclitaxel |
[142] | |
| PEI | HA, PLGA-ss-PEI (reducible bond) or PLGA-PEI (non-reducible bond), docetaxel, siRNA | Polymeric micelle | In vitro + in vivo | Co-delivery: siRNA docetaxel |
[143] | |
| LPEI | HA-ss-siRNA (reducible bond) or HA-siRNA (non-reducible bond), LPEI | Polyelectrolyte complex | In vitro + in vivo | - | [140] | |
| bPEI | HA, bPEI, polysiRNA | Polyelectrolyte complex | In vitro + in vivo | - | [138] | |
| CS | HA, CS, TPP, siRNA | Nanogel | In vitro | - | [134] | |
| Protamine | HA-taurocholic acid, protamine, siRNA | Polyelectrolyte complex | In vitro + in vivo | - | [144] | |
| Protamine | HA, Protamine, epigallocatechin-3-O-gallate (EGCG), CPP, siRNA | Nanogel | In vitro + in vivo | Co-delivery: siRNA EGCG |
[145] | |
| Covalent linking | bPEI | HA-ss-(Octandioic acid-g-bPEI) or HA-(Octandioic acid-g-bPEI), paclitaxel, siRNA | Polymeric micelle | In vitro + in vivo | Co-delivery: siRNA paclitaxel |
[146] |
| bPEI | HA-bPEI, HA-PEG, HA-Hexyl fatty acid, Cholesterol-siRNA | Polymeric micelle | In vitro + in vivo | - | [137] | |
| bPEI | Selected system after HA derivatives screening: HA-PEI, HA-PEG, siRNA or cisplatin Other HA-derivatives studied: HA-butylamine, HA-hexylamine, HA-octylamine, HA-stearylamine, HA-1,6 diaminohexane, HA-1,8 diaminooctane, HA-choline, HA-spermine, |
Polyelectrolyte complex | In vitro + in vivo | Sequential delivery: 1. NPs siRNA 2. NPs cisplatin |
[147,148,149] | |
| PEI | HA-PEI, siRNA | Polyelectrolyte complex | In vitro + in vivo | - | [150] | |
| PEI | HA-PEI, heparin, Ca2+, siRNA | Polyelectrolyte complex | In vitro | - | [151] | |
| Spermine | HA-spermine, siRNA | Polymeric micelle | In vitro | - | [152] | |
| pDMAEMA | HA-pDMAEMA- 2-(2-pyridyldithio) ethylamine (PDA), siRNA | Polyelectrolyte complex | In vitro + in vivo | - | [153] |