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. 2019 Jul 18;11(7):351. doi: 10.3390/pharmaceutics11070351

Figure 4.

Figure 4

Three-dimensional atomic force microscopy (AFM) images of (a) Hsp27 siRNA in complex with TEA-core PAMAM dendrimers of increasing generation (G1–G7) and (b) a single spherical siRNA/TEA-core dendrimer (G7) complex at a final siRNA concentration of 0.0125 mg/L and at a dendrimer-to-siRNA charge ratio (N/P) of 10. (c) Gel retardation of Hsp27 siRNA with three different TEA-core PAMAMs ((G1) (a), (G4) (b) and (G7) (c)) as a function of the N/P ratio (from 10/1 to 1/10 from left to right; last lane: Naked siRNA). Adapted from [41] with the permission of the RSC.