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. 2019 Jul 18;11(7):351. doi: 10.3390/pharmaceutics11070351

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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(a) Effect of cytochalasin D (a macropinocytosis inhibitor, red bars), genistein (a caveolae-mediated endocytosis inhibitor, light blue bars), and chlorpromazine (a clathrin-mediated endocytosis inhibitor, gray bars) on the uptake of Alexa 647-labelled A₅/T₅ ssiRNA/G₅ TEA-core dendrimer nanoparticles by PC-3 cells. Values are normalized to Alexa 647-labeled ssiRNA/G₅ TEA-core dendrimer nanoparticles uptake in the absence of any inhibitor. (b) Colocalization of the Alexa 647-labelled A₅/T₅ ssiRNA/G₅ TEA-core dendrimer nanoparticles with different endocytosis biomarkers: Top panel, dextran (macropinocytosis biomarker); middle panel, cholera toxin B (caveolae-mediated endocytosis biomarker); bottom panel, transferrin (clathrin-mediated endocytosis biomarker).