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Pharmacokinetic parameters of DTZ and DTZM estimated by one-compartmental analysis of the mean concentration–time profiles after the oral administration of 120 mg of DTZ to 19 healthy subjects.
| Parameter | DTZ | DTZM |
|---|---|---|
| ke (1/h) | 0.2861 | 0.0945 |
| ka (1/h) | 0.0655 | 0.492 |
| Tlag (h) | 0.36 | 0.162 |
| Cmax (ng/mL) | 120.5 | 6.04 |
| Tmax (h) | 2.51 | 4.20 |
| AUC0–∞ (ng/mL·h) | 800.9 | 94.66 |
| t1/2 (h) | 2.42 | 7.34 |
