Table 1.

Selected examples of novel bacterial secondary metabolites discovered via genome mining approaches

Compound	Class	Activity	BGC original host	Identification strategy	Reference
Scleric acid	(2‐(benzoyloxy) acetyl)‐L‐proline	Mycobacterium tuberculosis	Streptomyces sclerotialus NRRL ISP‐5269	Heterologous expression in Streptomyces albus J1074	(Alberti et al., 2019)
Enterocin	Polyketide	Cytotoxic	Salinispora pacifica CNT‐150	Heterologous expression in Streptomyces coelicolor M1146	(Bonet et al., 2014)
Borregomycin A	Indolotryptoline	CaMKIIδ kinase inhibition	Metagenomic DNA from Anza‐Borrego Desert soil	Heterologous expression in Streptomyces albus J1074	(Chang and Brady, 2013)
Avermectins	Polyketides	Antihelminthic	Streptomyces avermitilis ATCC 31267	Heterologous expression in Streptomyces lividans 1326	(Deng et al., 2017)
Tetarimycin A	Polyketide	MRSA	Metagenomic DNA	Heterologous expression in Streptomyces albus J1074	(Kallifidas et al., 2012)
Cosmomycins	Polyketides	Cytotoxic	Streptomyces sp. CNT‐302	Heterologous expression in Streptomyces coelicolor M512	(Larson et al., 2017)
Alterochromide	Lipopeptide	Antibacterial, cytotoxic	Pseudoalteromonas piscicida JCM 20779	Heterologous expression in Escherichia coli BL21(DE3)	(Ross et al., 2015)
Taromycin A	NP peptide	Antibacterial	Saccharomonospora sp. CNQ490	Heterologous expression in Streptomyces coelicolor M512	(Yamanaka et al., 2014)
Streptoseomycin	Polyketide	Helicobacter pylori	Streptomyces seoulensis A01	Heterologous expression in Streptomyces chartreusis 1018	(Zhang et al., 2018)
Actinoallolides	Polyketides	Anti‐trypanosomal	Actinoallomurus fulvus MK10‐037	Heterologous expression in Streptomyces coelicolor M1152	(Inahashi et al., 2018)
Thaxtomins	Nitrated diketopiperazines	Herbicide	Streptomyces scabiei 87.22	Heterologous expression in Streptomyces albus J1074	(Jiang et al., 2018)
Syringolin	NR peptide	Cytotoxic	Pseudomonas syringae pv. syringae (Pss) B728a	Heterologous expression in Streptomyces lividans TK24	(Huang et al., 2018)
Pseudomycoicidin	Lantibiotic	Antibacterial	Bacillus pseudomycoides DSM 12442	Heterologous expression in Escherichia coli BL21(DE3)	(Basi‐Chipalu et al., 2015)
Amicoumacin	Dihydroisocoumarin	Antibacterial	Bacillus subtilis 1779	Heterologous expression in Bacillus subtilis JH642	(Li et al., 2015)
Pyxidicyclines	Polyketides	Topoisomerase inhibitor	Pyxidicoccus fallax An d48	BGC activation and heterologous expression	(Panter et al., 2018)
Chattamycins	Polyketides	Cytotoxic	Streptomyces chattanoogensis L10	Overexpression of pathway‐specific activator	(Zhou et al., 2015)
Stambomycins	Polyketides	Cytotoxic	Streptomyces ambofaciens ATCC 23877	Overexpression of pathway‐specific activator	(Laureti et al., 2011)
Coelimycin P1	Polyketide	Antibacterial	Streptomyces coelicolor A3(2)	Inactivation of pathway‐specific repressor	Gomez‐Escribano et al., 2012;
Gacamide A	Lipopeptide	Antibacterial	Pseudomonas fluorescens Pf0‐1	Repair of defective pathway‐specific activator	Jahanshah et al., 2019;
Atolypenes	Sesterterpenes	Cytotoxic	Amycolatopsis tolypomycina NRRL B‐24205	Cas9‐TAR BGC refactoring	Kim et al., 2018