Table 2.
Co-administration Ratio | MCF-7 (% of Inhibition) | MDA-MB-231 (% of Inhibition) | ||
---|---|---|---|---|
Compound (IC50): TP5-iRGD | ZER | ZER-HPβCD | ZER | ZER-HPβCD |
1:10 X | 91.4 ± 3.0 | 90.4 ± 4.2 | 58.1 ± 8.8 | 41.5 ± 20.4 |
1:20 X | 67.6 ± 3.9 | 85.8 ± 7.0 | 44.0 ± 8.6 | 72.8 ± 2.3 |
1:30 X | 72.1 ± 8.6 | 68.5 ± 13.2 | 48.3 ± 5.4 | 79.1 ± 1.8 |
Data are presented as mean ± SD; ZER: zerumbone, ZER-HPβCD: zerumbone encapsulated in hydroxypropyl-β-cyclodextrin.