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. 2019 Jul 4;11(7):314. doi: 10.3390/pharmaceutics11070314

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Hydrofilms characterisation. (A) Swelling curve. The percentage of water uptake regarding dry weight of the hydrofilms at different time points. ***p < 0.001 among mHF-Lac, bilayer hydrofilms (bHF and bHF+Chit) and monolayer hydrofilms crosslinked with citric acid (mHF-CA and mHF-CA+Chit). (B) Water vapour transmission rate (WVTR). Graphical representation of the WVTR of the hydrofilms ***p < 0.001 comparing mHF-Lac with bHF and bHF+Chit. Results are given as mean ± SD. (C) Cytotoxicity assay. Cell viability after incubating fibroblasts with the release medium of hydrofilms. *p < 0.05 comparing dialysed and humected formulations. Results are shown as mean ± SD.