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. 2019 Jul 14;9(7):165. doi: 10.3390/brainsci9070165

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Late pre-symptomatic DPSC-CM treatment in mSOD1^G93A mice significantly attenuated ventral horn MN loss. Daily systemic DPSC-CM treatment from PD70–91 significantly increased MN survival in the mSOD1^G93A mouse lumbar spinal cord ventral horn compared to vehicle treatment, as measured by NeuN+ cells (green) in the ventral horn. Motor neurons in both Vehicle (Veh) and DPSC-CM treated mSOD1^G93A mice were significantly less than those in wild-type (WT) mouse lumbar spinal cord. Blue labeling indicates cell nuclei. Data represent mean +/− SEM. Data analyzed via one-way ANOVA. (WT, n = 3; mSOD1^G93A, n = 5–6). *, p < 0.05; ***, p < 0.001. Scale bar = 150 μm.