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. 2019 Jul 14;9(7):165. doi: 10.3390/brainsci9070165

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Astrocyte reactivity in the lumbar ventral horn of mSOD1^G93A mice was not significantly affected by late pre-symptomatic DPSC-CM therapy. Assessment of astrocyte reactivity via percent area of the ventral horn (dashed white line) occupied by GFAP+ labeling (red) showed no significant difference between DPSC-CM and vehicle treated mSOD1^G93A mice. Both treatment groups showed similar significant elevation of astrocyte reactivity during this stage of disease compared to WT mice. Data represent mean +/− SEM. Data analyzed via one-way ANOVA. (WT, n = 3; mSOD1^G93A, n = 5–6). **, p < 0.01; ***, p < 0.001. CC = central canal. Scale bar = 100 μm.