Table 3.
Characterisation of the solid B-SNEDDS. Results are reported as mean ± SD (n = 3).
| Code | Aerosil Type | Carrier: B-SNEDDS Ratio (w/w) | Yield (%) | Angle of Repose (°) | Drug Loading (%) | Particle Size (nm) | Butenafine Released at 60 min in SGF (%) |
|---|---|---|---|---|---|---|---|
| F1 | 200 | 1:2 | 71.1 ± 1.6 | 19.1 ± 5.4 | 94.1 ± 0.1 | 119.8 ± 2.3 | 45 ± 2.0 |
| F2 | 200 | 1:3 | 66.5 ±10.2 | 15.9 ± 3.0 | 96.5 ± 2.4 | 25.9 ± 1.2 | 28 ± 5.0 |
| F3 | R972 | 1:2 | 32.9 ± 1.3 | 20.6 ± 0.2 | 85.5 ± 4.6 | 279 ± 8.7 | 18 ± 4.0 |
| F4 | R972 | 1:3 | 47.4 ± 22.6 | 8.7 ± 1.5 | 97.0 ± 2.1 | 1 * | 20 ± 0.2 |
* Particle size measurements of F4 were registered as 1 nm, indicating that particles were not stable upon dilution.