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Effects of withanolides on histological changes in skin lesions of mice on day 6 of treatment (hematoxylin-eosin HE staining ×400. (A) Control group. (B) IMQ-treated group. (C) Withanolides 500 mg/kg group. (D) Withanolides 250 mg/kg group. (E) MTX-treated group. (F) Epidermal thickness in the dermis. Epidermal thickness in the dermis was measured in five randomly chosen fields (mean ± SD, n = 5). ** p < 0.01 vs. IMQ-treated group, *** p < 0.001 vs. IMQ-treated group.
