Table 2.
Comparison of prognostic factors in patients with sepsis with or without TPE.
| TPE Use during Sepsis | p-Value | |||
|---|---|---|---|---|
| Yes (n = 29), Median (Min–Max) | No (n = 139), Median (Min–Max) | |||
| Sex (male) | 13 (44.8%) | 73 (52.5%) | 0.451 | |
| Age, years | 5.0 (5 months–17.83 years) | 3.0 (2 days–17.58 years) | 0.761 | |
| IMV support | 14 (48.3%) | 67 (48.2%) | 0.942 | |
| Inotropic drug use | 21 (72.4%) | 72 (51.8%) | 0.042 | |
| Albumin use | 23 (79.3%) | 72 (51.9%) | 0.008 | |
| RBC transfusion | 28 (96.6%) | 103 (74.1%) | <0.001 | |
| IVIG use | 13 (44.8%) | 47 (33.8%) | 0.260 | |
| NIV support | 13 (44.8%) | 72 (51.8%) | 0.495 | |
| Mortality | 7 (24.1%) | 18 (12.9%) | 0.124 | |
| Duration of stay in PICU | 6.0 (27 h–48 d) | 7.0 (26 h–97 d) | 0.761 | |
| PRISM III score | 28 (6–55) | 21 (3–65) | 0.195 | |
| Multi-organ failure | 15 (51.7%) | 57 (41.0%) | 0.289 | |
| Laboratory findings | Sodium (mmol/L) | 136.0 (119.0–182.0) | 138.0 (119.0–161.0) | 0.399 |
| Chlorine (mmol/L) | 99.9 (84.2–150.0) | 102.0 (84.8–121.0) | 0.937 | |
| Calcium (mg/dL) | 8.0 (5.6–10.6) | 9.0 (6.4–11.3) | <0.001 | |
| Magnesium (mg/dL) | 1.64 (1.10–4.11) | 2.00 (0.89–4.00) | 0.507 | |
| ALT (IU/L) | 43 (7–4388) | 20 (4–1620) | <0.001 | |
| AST (IU/L) | 51 (19–8620) | 36 (8–1954) | <0.001 | |
| PT (s) | 16.8 (11.2–28.3) | 15.6 (1.3–26.6) | 0.318 | |
| aPTT (s) | 41.6 (27.7–124.0) | 39.1 (18.8–124.0) | 0.226 | |
| INR | 1.42 (0.90–2.40) | 1.40 (0.80–2.20) | 0.455 | |
| LDH (IU/L) | 539 (1–6310) | 393 (126–2591) | <0.001 | |
| CRP (mL/dL) | 8.1 (0.74–405.9) | 11.6 (0.3–467.0) | 0.408 | |
| Leucocyte count (mm3) | 7100 (200–54,600) | 12095 (13–111,800) | 0.216 | |
| Uric acid (mg/dL) | 5.7 (1.0–17.8) | 3.5 (1.0–16.2) | 0.004 | |
| Haemoglobin (g/dL) | 8.0 (6.1–11.2) | 9.6 (5.6–19.3) | 0.007 | |
| Platelet count (103/µL) | 84 (24–410) | 228 (6–899) | <0.001 | |
| HCO3 (mmol/L) | 13.9 (9.0–35.3) | 19.2 (3.5–37.0) | 0.150 | |
| Lactate (mmol/L) | 4.5 (0.5–16.0) | 2.5 (0.5–29.0) | 0.160 | |
Abbreviations: IMV, invasive mechanical ventilation; RBC, red blood cell; IVIG, intravenous immunoglobulin; NIV, non-invasive mechanical ventilation; PICU, paediatric intensive care unit; ALT, alanine transaminase; AST, aspartate aminotransferase; PT, prothrombin time; aPTT, activated partial thromboplastin time; INR, international normalised ratio; LDH, lactate dehydrogenase; CRP, C-reactive protein.