Figure 2.

Modulation of global transcriptional profiles during oral cancer chemoprevention by BRBs (A) Heat map showing differentially expressed genes from rat tongues during 4NQO induced oral carcinogenesis and BRB mediated oral cancer chemoprevention. 4NQO exposed rats were fed a control diet, 5% BRB, or 10% BRB supplemented diet. (B) Ingenuity pathway analysis of the canonical transcriptional pathways modulated by dietary BRB intervention during oral carcinogenesis. Transformed RNA sequencing data from rat tongue RNA from 4NQO exposed, BRB treated, and untreated rat groups were analyzed using Ingenuity Pathway Analysis software (Qiagen).