Table 1.
Predicted pathway activity profiles based on the pathway analysis of LC-MS data from rat urine samples of 4NQO exposed rats fed control diet, or diet supplemented with 5% or 10% BRB as determined using Mummichog in MetaboAnalyst. Significant hits represent differentially expressed metabolites in the predicted pathway between rat groups.
| Predicted Metabolic Pathways | Total Metabolite Hits | Significant Metabolite Hits |
|---|---|---|
| Steroid hormone biosynthesis | 15 | 11 |
| Glyoxylate and dicarboxylate metabolism | 6 | 5 |
| Vitamin B6 metabolism | 5 | 4 |
| Cysteine and methionine metabolism | 9 | 5 |
| Riboflavin metabolism | 2 | 2 |
| Tryptophan metabolism | 11 | 5 |
| One carbon pool by folate | 6 | 3 |
| Porphyrin and chlorophyll metabolism | 9 | 4 |
| Glycerophospholipid metabolism | 7 | 3 |
| Pyrimidine metabolism | 13 | 5 |
| Citrate cycle (TCA cycle) | 4 | 2 |
| Ascorbate and aldarate metabolism | 5 | 2 |
| Primary bile acid biosynthesis | 5 | 2 |
| Pantothenate and CoA biosynthesis | 5 | 2 |
| Purine metabolism | 24 | 8 |
| Folate biosynthesis | 6 | 2 |
| Inositol phosphate metabolism | 7 | 2 |
| Arginine and proline metabolism | 18 | 5 |
| Starch and sucrose metabolism | 12 | 3 |
| Pentose phosphate pathway | 8 | 2 |
| Tyrosine metabolism | 13 | 3 |
| Glutathione metabolism | 9 | 2 |
| Biosynthesis of unsaturated fatty acids | 9 | 2 |
| Glycolysis or Gluconeogenesis | 10 | 2 |
| Alanine, aspartate and glutamate metabolism | 10 | 2 |
| Fructose and mannose metabolism | 11 | 2 |
| beta-Alanine metabolism | 11 | 2 |
| Aminoacyl-tRNA biosynthesis | 17 | 3 |
| Galactose metabolism | 19 | 3 |
| Amino sugar and nucleotide sugar metabolism | 20 | 3 |