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. 2019 Jul 17;9(7):287. doi: 10.3390/biom9070287

Figure 5.

Figure 5

Schematic representation of the DRMs bilayer molecular organization. The body of our results, Langmuir isotherm and X-ray scattering experiments, suggest that an ordered phase made of saturated lipids (sphingolipids and gangliosides) and cholesterol is formed (blu), named “cholesterol-rich Lo phase”, together with a more fluid Ld phase made of unsaturated lipids (red). From X-ray scattering results, d1 = 57.2 and d4 = 4.2 Å could be associated with the “cholesterol-rich Lo phase”. A less ordered Ld phase, characterized by d2 = 39.9 and d5 = 3 Å, is also present. Both phases are typical of the lipid-rafts and are present even in the absence of Cav-1 (KO-DRMs). In the presence of Cav-1 a “caveolin-induced Lo phase” can be formed, embedded in the first and characterized by d3 = 34 and d4 = 4.2 Å.