Figure 7.

Differential wiring of the cospliced genes in the methamphetamine high drinking (MAHDR) and methamphetamine low drinking (MALDR) lines. To facilitate comparison across regions, the connectivity and number of edges are computed only for the genes shared in common across the brain regions. The numbers of changed edges for the cosplicing networks are shown in (a) for the ventral midbrain (VMB) and (b) for the prefrontal cortex (PFC). The nucleus accumbens (NAc) is not represented, because the data from the NAc did not follow a power law distribution, making it impossible to assess differential wiring for the cosplicing networks. Genes significantly enriched in changed edges, relative to other genes in the same network, are depicted in red.