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Mean arterial plasma concentration-time profiles of tofacitinib in Sprague-Dawley rats after (A) 1-min intravenous infusion of 5 (n = 9), 10 (n = 8), 20 (n = 7), and 50 (n = 7) mg/kg tofacitinib and (B) oral administration of 10 (n = 7), 20 (n = 8), 50 (n = 9), and 100 (n = 7) mg/kg tofacitinib. Bars represent standard deviations (SD).
