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(A) Mean plasma and tissue/organ concentrations of tofacitinib and (B) tissue-to-plasma (T/P) ratios of tofacitinib 30 min (n = 4) and 2 h (n = 4) in Sprague-Dawley rats after 1-min intravenous infusion of 10 mg/kg tofacitinib. Data are expressed means ± standard deviations (SD). LI; large intestine, SI; small intestine.
