Table 3.
Pharmacokinetic parameters of tofacitinib after 30-min intravenous and intraportal infusion of the drug at dose of 10 mg/kg to male Sprague-Dawley rats.
| Parameter | Intravenous | Intraportal |
|---|---|---|
| (n = 7) | (n = 7) | |
| Body weight (g) | 292 ± 18.0 | 299 ± 28.6 |
| AUC (μg∙min/mL) | 417 ± 136 | 242 ± 66.0 ** |
| Terminal half-life (min) | 46.2 ± 12.5 | 42.4 ± 10.4 |
| MRT (min) | 67.5 ± 26.8 | 59.6 ± 13.9 |
| CL (mL/min/kg) | 26.3 ± 8.85 | 43.8 ± 11.0 ** |
| CLR (mL/min/kg) | 2.34 ± 2.90 | 5.00 ± 4.69 |
| CLNR (mL/min/kg) | 24.0 ± 6.46 | 38.5 ± 10.4 ** |
| Vss (mL/kg) | 1695 ± 737 | 2549 ± 720 * |
| Ae0–24 h (% of dose) | 12.5 ± 5.20 | 10.7 ± 9.42 |
Data are expressed as mean ± standard deviation (SD). * p < 0.05; ** p < 0.01.