Table 4.
Non‐cancer points of departure (POD) and Reference dose (RfD) Array
| Species/Sex | Endpoint | BMD10 mg/kg‐day | POD (BMDL10) mg/kg‐day | HED mg/kg‐day | UFa Unitless | RfD mg/kg‐day |
|---|---|---|---|---|---|---|
| Mice | Forestomach | |||||
| Female | Hyperplasia | 88.7 | 70.5 | 11.6 | 30 | 0.4 |
| Ulcer | 102.2 | Not Calculated | ||||
| Infiltration | 106.3 | Not Calculated | ||||
| Inflammation | 105.5 | Not Calculated | ||||
| Mice Male | Hyperplasia | 103 | Not Calculated | |||
| Ulcer | 190.5 | Not Calculated | ||||
| Infiltration | 175.6 | Not Calculated | ||||
| Inflammation | 218.1 | Not Calculated | ||||
| Rat, Female | Uterine endometrial atypical hyperplasia | 118.7 | 72.8 | 18.2 | 30 | 0.6 |
| Rat, Female | Rete ovarian cysts | 596.7 | 355.4 | 88.9 | 30 | 3.0 |
a
UFA=3; UFH=10.