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. 2019 Jul 29;11:7159–7169. doi: 10.2147/CMAR.S217170

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© 2019 Zhou et al.

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Analysis of the ability of serum ANGPTL2 levels to diagnose AFP-negative HCC.

Notes: (A) ANGPTL2-positive rates in patients with HCC stratified by AFP status. (B) ROC curves for patients with HCC versus HCs in the discovery cohort; (C) ROC curves for patients with HCC versus HCs in the validation cohort; (D) ROC curves for patients with HCC versus high-risk controls (CHB + LC) in the validation cohort; (E) ROC curves for patients with HCC versus all controls (HC+CHB+LC) in the validation cohort. AFP <13.4 ng/ml is clinically normal and is considered as negative.

Abbreviations: ANGPTL2, angiopoietin-like protein 2; AFP, alpha-fetoprotein; HCC, hepatocellular carcinoma; HC, healthy control; CHB, chronic hepatitis B; LC, liver cirrhosis; ROC, receiver operating characteristics; AUC, area under the curve; CI, confidence interval.