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. 2019 Jul 12;11(7):331. doi: 10.3390/pharmaceutics11070331

Figure 7.

Figure 7

Representative images of acridine-orange and Hoescht stained SH-SY5Y and hCMEC/D3 cells treated with PCL@C6 NPs at 50 µg/mL for 24 and 5 h, respectively (a); accumulation (solid bars) and relative efficiency uptake (patterned bars) of PCL@C6 NPs (50 and 100 µg/mL) in SH-SY5Y and hCMEC/D3 cells after 24 and 5 h of exposure, respectively (b); evaluation of the MAO-B inhibitory capacity in SH-SY5Y cells after 8 h of exposure, using kynuramine (KYN) as the substrate and clorgyline (Clorg) and selegiline (Seleg) as standard inhibitors of MAO-A and MAO-B, respectively (c). The results are expressed as mean ± SD (n = 3) and statistical comparisons were made using two-way ANOVA and one-way ANOVA, in cases (b) and (c), respectively. In all cases, p-values lower than 0.05 were considered significant (**** p < 0.0001 by comparison of different concentrations tested concentration; ## p < 0.01, ### p < 0.001, and #### p < 0.0001 by comparison the results obtained between the two cell lines tested; ΨΨΨΨ p < 0.0001 by comparison with untreated cells; •••• p < 0.0001 by comparison with cells treated only with kynuramine). The dashed red line represents the control data.