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. 2019 Jul 31;11:249–259. doi: 10.2147/BCTT.S208706

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© 2019 Liang et al.

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APR-246 and 2aG4 treatment inhibits metastasis of MDA-MB-435 TNBC cells to the lungs in nude mice.

Notes: (A) Female nude mice were inoculated with MDA-MB-435 cells and then treated with C44 antibody (control), APR-246, 2aG4, or a combination of APR-246 and 2aG4 following the protocol described in Figure 5A. Data represent mean number of lung colonies±SEM (n=10–11/group) obtained at the end of the experiment. *Significantly different from control (P<0.05, ANOVA on ranks followed by Dunn’s test). (B) Representative images of lungs from four different animals from each group; colonies appear as off-white specks on the lungs (an example is circled).

Abbreviations: ANOVA, analysis of variance; SEM, standard error of the mean; TNBC, triple-negative breast cancer.