Table 2.
Genotype and allele frequencies of the HNF1A polymorphisms in cases and controls
| SNP/genotype/allele | Control (%) | CAD (%) | IS (%) | p CAD | p IS |
|---|---|---|---|---|---|
| Rs1169288 | |||||
| AA | 259 (43.7) | 258 (45.9) | 237 (45.5) | ||
| AC | 263 (44.4) | 236 (42) | 214 (41.1) | ||
| CC | 71 (12) | 68 (12.1) | 70 (13.4) | 0.706 | 0.504 |
| A | 781 (65.9) | 752 (66.9) | 688 (66) | ||
| C | 405 (34.1) | 372 (33.1) | 354 (34) | 0.597 | 0.964 |
| p HWE | 0.736 | 0.220 | 0.054 | ||
| Rs2259820 | |||||
| CC | 189 (31.9) | 194 (34.6) | 183 (35.1) | ||
| CT | 285 (48.1) | 282 (50.3) | 247 (47.4) | ||
| TT | 119 (20.1) | 85 (15.2) | 91 (17.5) | 0.088 | 0.387 |
| C | 663 (55.9) | 670 (59.7) | 613 (58.8) | ||
| T | 523 (44.1) | 452 (40.3) | 429 (41.2) | 0.070 | 0.170 |
| p HWE | 0.539 | 0.289 | 0.627 | ||
| Rs2464196 | |||||
| GG | 189 (31.9) | 194 (34.6) | 181 (34.8) | ||
| GA | 284 (47.9) | 283 (50.5) | 248 (47.7) | ||
| AA | 120 (20.2) | 83 (14.8) | 91 (17.5) | 0.053 | 0.404 |
| G | 662 (55.8) | 671 (59.9) | 610 (58.7) | ||
| A | 524 (44.2)) | 449 (40.1) | 430 (41.3) | 0.052 | 0.183 |
| p HWE | 0.480 | 0.218 | 0.703 | ||
| Rs2650000 | |||||
| CC | 217 (36.5) | 214 (38.1) | 205 (39.3) | ||
| CA | 278 (46.8) | 260 (46.3) | 238 (45.7) | ||
| AA | 99 (16.7) | 88 (15.7) | 78 (15) | 0.825 | 0.560 |
| C | 712 (59.9) | 688 (61.2) | 648 (62.2) | ||
| A | 476 (40.1) | 436 (38.8) | 394 (37.8) | 0.551 | 0.277 |
| p HWE | 0.534 | 0.541 | 0.513 |
p CAD, the p value of CAD versus control; p IS, the p value of IS versus control; p HWE, the p value of the Hardy–Weinberg equilibrium (HWE).