Table 1.
General characteristics of included RCTs
| Features of included RCTs | N | ％ (n/137) |
|---|---|---|
| Publication year | ||
| Before 2010 | 32 | 23% |
| After 2010 | 105 | 77% |
| Sample size [Median (IQR)] | 68 (60–87) | |
| <80 | 91 | 66% |
| ≧80 | 46 | 34% |
| Research centers | ||
| Single center | 132 | 96% |
| Multi-center | 5 | 4% |
| Number of arms | ||
| 2 arms | 124 | 91% |
| >2 arms | 13 | 9% |
| The main effect of the primary outcome | ||
| Significant | 127 | 93% |
| Insignificant | 10 | 7% |
| Sources of funding | ||
| Not-for-profit funding | 23 | 17% |
| For-profit funding | 0 | 0 |
| Clearly stated, not funded | 0 | 0 |
| Not reported | 114 | 83% |
| Was a protocol mentioned? | ||
| Yes | 0 | 0 |
| No | 137 | 100% |
| Was the study registered? | ||
| Yes | 0 | 0 |
| No | 0 | 0 |
| Not reported | 137 | 100% |