Table 5.
Frequency of ACPA specificities among RA patients in the Malaysian study who were ever smokers compared with nonsmokersa
| Ever smoker (n = 90) | Nonsmoker (n = 1,017) | ||||
|---|---|---|---|---|---|
| ACPA peptide antibody | Peptide positive | Peptide negative | Peptide positive | Peptide negative | P |
| Anti–CCP‐2 | 72 (80) | 18 (20) | 629 (61.8) | 388 (38.2) | 0.0009 |
| Fil307–324 | 45 (50) | 45 (50) | 408 (40.1) | 609 (59.9) | NS |
| Vim60–75 | 26 (28.9) | 64 (71.1) | 249 (24.5) | 768 (75.5) | NS |
| Vim2–17 | 61 (67.8) | 29 (32.2) | 526 (51.7) | 491 (48.3) | 0.004 |
| Fibβ36–52 | 50 (55.6) | 40 (44.4) | 455 (44.7) | 562 (55.3) | NS |
| Fibα563–583 | 50 (55.6) | 40 (44.4) | 360 (35.4) | 657 (64.6) | 0.0002 |
| Fibα580–600 | 26 (28.9) | 64 (71.1) | 184 (18.1) | 833 (81.9) | 0.01 |
| Fibβ62–81a | 25 (27.8) | 65 (72.2) | 175 (17.2) | 842 (82.8) | 0.01 |
| Fibβ62–81b | 16 (17.8) | 74 (82.2) | 148 (14.6) | 869 (85.4) | NS |
| Eno5–21 | 36 (40) | 54 (60) | 207 (20.4) | 810 (79.6) | <0.0001 |
| CitCII355–378 | 17 (18.9) | 73 (81.1) | 171 (16.8) | 846 (83.2) | NS |
a
Information on smoking was missing for 124 RA patients. Values are the number (%). See Table 2 for definitions.