Figure 4.

The scavenging role of stabilin maintains homeostasis in the liver by the uptake of products of oxidative stress. Stabilin-1 contributes to the hepatic uptake of circulating oxidized low-density lipoproteins (oxLDLs). In the setting of stabilin-1 deficiency, these oxLDLs lead to a proinflammatory response specifically, leading to increased levels of the chemokine CCL3, which drives the proliferation of liver-resident fibroblasts and causes an increase in collagen fibres in the livers of stabilin-1 knockout mice.