Table 1.
Summarizing data: Influence of intranasally administered lunasin (0.1 and 1 nmol/mouse) on locomotor activity (distance, cm) and brain monoamine levels (ng/g), changed by amphetamine (3 mg/kg i.p.) and DOI (3 mg/kg i.p.).
| Compounds | Locomotion | DA | HVA | DOPAC | 5-HT | 5-HIAA | NA |
|---|---|---|---|---|---|---|---|
| Amphetamine | ↑ | ↑ | ↑ | Nc | ↑ | ↑ | ↑ |
| Amphetamine + Lunasin 0.1 | N | N | Nc | Nc | Nc | N | N |
| Amphetamine + Lunasin 1 | N | N | N | Nc | N | N | Nc |
| DOI | ↑ | Nc | ↓ | ↑ | ↑ | ↑ | ↓ |
| DOI + Lunasin 0.1 | Nc | Nc | Nc | Nc | N | N | N |
| DOI + Lunasin 1 | N | Nc | N | Nc | N | N | N |
| Lunasin 0.1 | Nc | ↓ | Nc | Nc | Nc | Nc | Nc |
| Lunasin 1 | Nc | ↓ | Nc | Nc | Nc | Nc | Nc |
↑—increase; ↓—decrease; N—normalization; Nc—no changes.