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. 2018 May 23;39(8):1516–1530. doi: 10.1177/0271678X18776820

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© The Author(s) 2018

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 6. — (a) Transaxial (top row) and sagittal (bottom row) images representing CMRGlc derived using the AIF (left) and the IDIF (right) for a subject with a 3% AUC overestimation by IDIF. Images show excellent agreement in absolute CMRGlc values. (b)Relative %-differences for six reference regions (cerebellum, brainstem, anterior cingulate cortex, thalamus, corpus callosum and superior frontal cortex) in all 20 scans. The shaded areas depict test/retest scans obtained in the same subject. (c)Histogram depicting the % absolute differences in CMRGlc values derived using the IDIF and the AIF. The graph shows a maximum for difference values in the range of 2–4%, with 85% of all differences laying within 5%.