Table 3.
Discriminatory ability comparison of the three in vitro release testing methods as well as ex vivo permeation method based on the Wilcoxon Rank Sum/Mann-Whitney rank test.
| Ratio | Test: | F2 | F4 | F4 | F4 | F3 |
|---|---|---|---|---|---|---|
| Order | Reference: | F1 | F1 | F2 | F3 | F2 |
| In vitro release testing using Franz Diffusion Cell | ||||||
| 8th (%) | 102.3 | 178.1 | 139.5 | 104.7 | 115.4 | |
| 29th (%) | 143.2 | 223.7 | 187.8 | 105 | 166.7 | |
| In vitro release testing using USP Apparatus 2 | ||||||
| 8th (%) | 116.5 | 235.7 | 180.9 | 126.4 | 133.3 | |
| 29th (%) | 151.4 | 300 | 222.4 | 146.5 | 166.9 | |
| In vitro release testing using USP Apparatus 4 | ||||||
| 8th (%) | 142.5 | 224.3 | 144.2 | 114.2 | 112.0 | |
| 29th (%) | 162.3 | 286.5 | 185.2 | 148.9 | 145.1 | |
| Ex vivo permeation using spherical joint FDC | ||||||
| 8th (%) | 98.1 | 153.0 | 129.6 | 104.8 | 104.3 | |
| 29th (%) | 141.6 | 232.0 | 189.0 | 157.5 | 164.0 | |