Table 2:

Percent Change in Urinary Estrogen Compounds and Metabolites for Preeclampsia (PE) compared with Controls

	5.3–15.3 weeks (PE=64 Controls=133)				15.4–21.7 weeks (PE=59 Controls=130)				23.1–29.3 weeks (PE=61 Controls=131)
EM Measures	% Δ^a	p	% Δ^{^b}	p	% Δ^a	p	% Δ^{^b}	p	% Δ^a	p	% Δ^{^b}	p
Total Estrogens	5.1	0.64	9.4	0.43	−13.9	0.05	−11.3	0.15	−12.7	0.04	−5.7	0.42
Parent Estrogens	22.7	0.13	16.8	0.27	2.6	0.84	−2.5	0.85	−14.3	0.16	−13.4	0.24
Estrone	19.8	0.20	13.4	0.40	−0.5	0.97	−6.5	0.64	−16.1	0.13	−16.1	0.17
Estradiol	45.6	<0.01	44.4	<0.01	21.5	0.10	23.9	0.09	−0.5	0.96	4.9	0.71
Total Metabolites	−2.4	0.82	2.3	0.85	−19.7	<0.01	−16.2	0.03	−12.2	0.07	−3.5	0.65
2-+4-Pathway Metabolites	−3.1	0.80	0.0	1.00	−23.2	0.03	−20.6	0.09	−28.5	<0.01	−25.8	0.03
2-Path	−9.3	0.41	−5.1	0.68	−23.3	0.03	−20.7	0.09	−25.5	0.02	−21.2	0.08
4-Path	−6.1	0.65	−9.8	0.49	−21.1	0.09	−18.5	0.19	−22.7	0.09	−20.4	0.16
16-Path	−1.3	0.91	3.3	0.81	−18.3	<0.01	−15.1	0.05	−12.4	0.08	−3.2	0.69
2-+4-Pathway Metabolites: Parent Estrogens	−23.2	0.02	−18.0	0.07	−25.1	0.01	−18.6	0.09	−14.1	0.16	−8.7	0.43
2-Path: Parent Estrogens	−23.0	0.02	−17.5	0.08	−25.3	0.01	−18.7	0.08	−14.5	0.14	−9.1	0.40
4-Path: Parent Estrogens	−25.5	0.05	−26.1	0.06	−21.4	0.14	−14.1	0.39	−7.2	0.62	−2.0	0.90
2-Path: 4-Path	−0.3	0.98	9.4	0.36	−4.9	0.60	−5.4	0.60	−10.9	0.19	−6.0	0.52

Models adjusted for maternal age, parity, and gestational age at sample collection.

Models adjusted for maternal age, parity, gestational age at sample collection, race, BMI, and use of ART.