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. Author manuscript; available in PMC: 2019 Aug 5.
Published in final edited form as: Oral Oncol. 2018 May 3;81:100–108. doi: 10.1016/j.oraloncology.2018.04.014

Fig. 4.

Fig. 4.

Protein structure and mechanisms of action of PRMT1 in SCCHN. A. Protein structure of PRMT1 (UniProt, 361 aminoacids, isoform 1). Signature motif I, post I, post II, post III, conserved TWH loop: tandem winged-helix. B. Mechanisms of action of PRMT1. PRMT1 and lymphotoxin-β (LTβ) are upregulated by Snail in SCCHN cells with EMT features. PRMT1 then methylates EGFR at R198/R200, and LTβ preferentially interacts with R198/R200-methylated EGFR, inducing its activation and resistance to Cetuximab.