Table 2.
Characteristics of the analyzed studies on endometrial transcriptomics for infertile women in natural and stimulated Cycle
| First author and reference | Participants population | N of patients | Age | Comparative | Region | Array | First sample (day, n) | Second sample (day, n) | N of genes up-regulated | N of genes down regulated |
|---|---|---|---|---|---|---|---|---|---|---|
| Infertile women | ||||||||||
| Natural cycles | ||||||||||
| Koler et al. [41] | women with unexplained infertility + fertile women | 32 | 19-40 | Infertile vs fertile | Europe | Array-Ready Oligo SetTM for the Human Genome Version 3.0 (Operon) |
cd21 Infertile women (n = 4) fertile women (n = 12 |
25 | 288 | |
| Altmae et al. [31] | women with unexplained infertility |
Infertile women (n = 4) Fertile women (n = 4) |
30.5+4.0 31.8+3.8 |
Infertile vs fertile | Europe | Whole Human Genome Oligo Microarray (Agilent Technologies) |
LH +7 Infertile women (n = 4) fertile women (n = 5) |
145 | 115 | |
| Koot et al. [34] | women experiencing RIF | 115 | 26-39 | Infertile vs fertile | Europe | Human whole genome gene expression microarrays V2 (Agilent) |
mid-luteal phase n = 115 |
303 genes predictive of RIF | 303 genes predictive of RIF | |
| Stimulated cycles | ||||||||||
| Liu et al. [25] | Infertile women with normal menstrual cycles | 47 | 26 -38 | NC vs CCOS | Hong Kong | HG_U133A (Affymetrix) |
LH+7 n = 5 |
hCG+7 n = 8 |
244 | 159 |
| Ruiz-Alonso et al. [36] | Patients with repeated implantation failure | 110 | 23-51 |
RIF vs controls pWOI/Pwoi delayed/pWOI advanced |
Europe | homemade ERA |
P+5 LH+7 |
- | - | |
| Altmae et al. [19] | Patients with repeated implantation failure | 15 | 30.2 ± 4.3 | Infertile vs fertile | Europe | Whole Human Genome Oligo Microarray (Agilent Technologies |
LH+7 (n = 5) P+6 (n = 5) |
443 | 446 | |
| Haouzi et al. [33] |
Oocyte-donation recipient patients RIF patients |
39 | 31-50 | NC vs HRT hormone replacement therapy | Europe | HGU133 plus 2.0 (Affymetrix) |
LH+7 (n = 7) P+5 (n = 7) |
1814 | 477 | |
Abbreviations: EP Early-proliferative, ES Early-Secretory, Ag Agonist, Atg Antagonist, LH+ LH surge + days, NC Natural cycle, COH Controlled ovarian hyperstimulation, MS mid-secretory, CCOS Controlled ovarian stimulation, PP proliferative phase, P+ Progesterone+ days, HRT hormone replacement therapy, pWO personalised window of implantation