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. 2019 Aug 2;9(3):2045894019859480. doi: 10.1177/2045894019859480

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© The Author(s) 2019

Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Fig. 2. — Increased mPAP and decreased cardiac index in irreversible PAH rats. (a) The systemic arterial pressure measured by catheterizing into the femoral artery were similar among the three groups. (b) The mPAP measured through a pulmonary arterial catheter was increased in rats from both the reversible PAH and irreversible PAH groups when compared to the control group. (c) The right ventricular hypertrophy index indicated by the ratio of RV/(LV+S) were significantly increased in the irreversible PAH group, but changed insignificantly in the reversible PAH group. (d) Cardiac index measured using Fick equation was significantly lower in the irreversible PAH group than in both the control and reversible PAH groups. The differences among the three groups (n = 10 in each group) were analyzed by one-way ANOVA followed by Bonferroni post hoc test. SBP, systemic blood pressure; mPAP, mean pulmonary arterial pressure; RV/(LV+S), right ventricle weight/(left ventricle + septum weight); CI, cardiac index. *P < 0.05 vs. control group, #P < 0.05 vs. reversible PAH group.