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. 2019 Aug 2;9(3):2045894019859480. doi: 10.1177/2045894019859480

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© The Author(s) 2019

Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Fig. 3. — Neointimal formation resulted in vascular obstructive lesions in small pulmonary arteries from irreversible PAH group rats. (a) Normal small pulmonary arteries without occlusion stained by elastic Van Gieson stain in the control group. (b) Medial hypertrophy with mild occlusion (<50%) in the reversible PAH group. (c) Neointimal formation with prominent occlusion (>50%) in the irreversible PAH group. (d) Significant vascular occlusive lesions assessed by vascular occlusion score developed in small pulmonary arteries from irreversible PAH rats (P < 0.05 vs. control group), while the occlusion was mild in the reversible PAH group with an insignificant difference with that in the control group. (e) The neointimal formation developed in most of investigated small pulmonary arteries from the irreversible PAH group, while only a very small amount of investigated small pulmonary arteries from the reversible PAH group developed neointimal formation. VOS, vascular obstruction score. #P < 0.05 vs. reversible PAH group.