Table 3.
Pooled estimates of the outcome parameters.
| Study | Mean follow-up duration (months) | Mortality rate (%/year) | Improvement in the estimate of the PAP (%) | Improvement in respiratory scores (%) |
|---|---|---|---|---|
| Mourani et al.30 | 7.9 ± 7.6 | 25.2 | NR | NR |
| Nyp et al.31 | 12.0 ± 2.9 | 19.0 | 70.0 | 14.3*†,‡ |
| Tan et al.32 | 9.0 ± 3.0 | 36.2 | 66.7 | 0.0§† |
| Trottier-Boucher et al.33 | 5.6 ± 2.4 | 74.3 | 71.4 | 34.8§†‡ |
| Kadmon et al.29 | 24.0 ± 15.6 | 2.9 | NR | NR |
| Pooled effect (95% CI) | 11.2 ± 7.5 | 27.6 (12.6–60.4) ** | 69.3 (56.8–81.8) †† | 15.0 (0.0–30.4) ** |
| I2 | 80.6 | 0.0 | 58.2 | |
| X2 P value | <0.001 | 0.9 | 0.05 |
*
Improvement within 48 h.
†
Using FiO2 measurements.
‡
Using RSS.
§
Improvement within 168 h.
**
Using random effects model.
††
Fixed effect model.
NR, variable not reported; PAP, pulmonary arterial pressure.