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. 2019 Jul 30;12:6105–6117. doi: 10.2147/OTT.S197454

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© 2019 Ge et al.

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FOXD2-AS1 bound to miR185-5p and negatively regulated its expression.

Notes: (A) Putative binding regions of FOXD2-AS1 in miR185-5p predicted with biological software. (B, C) Luciferase activity of wild-type or mutant FOXD2-AS1 in A549/DDP cells following miRNC, miR185-5p, anti-miRNC, or anti-miR185-5p transfection determined by luciferase reporter assay. (D) Correlations between FOXD2-AS1 and miR185-5p detected by RIP assay. (E, F) Expression of miR185-5p in DDP-resistant non-small-cell lung cancer (NSCLC) tissue and cell lines detected by RT-qPCR assay. (G, H) Expression of FOXD2-AS1 and miR185-5p in A549/DDP and H1299/DDP cells, initially transfected with pcDNA, pcDNA-FOXD2-AS1, si-NC, or si-FOXD2-AS1, determined by reverse-transcription (RT) qPCR assay. *P<0.05.