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. 2019 Jul 30;12:6105–6117. doi: 10.2147/OTT.S197454

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© 2019 Ge et al.

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SIX1 was a target of miR185-5p.

Notes: (A) Putative binding regions of miR185-5p in SIX1 3ʹUTR. (B, C) Luciferase activity of wild-type or mutant SIX1 in A549/DDP cells after transfection of miRNC, miR185-5p, anti-miRNC, or anti-miR185-5p. (D–F) mRNA and protein levels of SIX1 in DDP-resistant non-small-cell lung cancer (NSCLC) tissue and cell lines detected by reverse-transcription (RT) qPCR and Western blot assays. (G) Protein levels of SIX1 in miR185-5p or anti-miR185-5p–transfected A549/DDP and H1299/DDP cells. *P<0.05.