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. 2019 Jul 30;12:6105–6117. doi: 10.2147/OTT.S197454

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© 2019 Ge et al.

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FOXD2-AS1 reduced the chemosensitivity of DDP-resistant non-small-cell lung cancer (NSCLC) cells via the miR185-5p–SIX1 axis.

Notes: (A) miR185-5p expression in anti-miRNC or anti-miR185-5p–transfected A549/DDP and H1299/DDP cells. (B and C) SIX1 expression at mRNA and protein levels in si-NC or si-SIX1–transfected A549/DDP and H1299/DDP cells. (C) A549/DDP and H1299/DDP cells were transfected with si-NC, si-SIX1, si-SIX1 + anti-miRNC, or si-SIX1 + anti-miR185-5p, followed by evaluation of colony numbers (D), cell proliferation (E and F), migration (G), invasion (H), and drug resistance–related proteins LRP, Pgp, and MRP1 expression (I and J). (K) SIX1 expression in A549/DDP and H1299/DDP following transfection of si-NC, si-FOXD2-AS1, si-FOXD2-AS1 + anti-miRNC, or si-FOXD2-AS1 + anti-miR185-5p. *P<0.05.